{"id":34251,"date":"2025-01-03T15:32:57","date_gmt":"2025-01-03T13:32:57","guid":{"rendered":"https:\/\/marsci.haifa.ac.il\/?p=34251"},"modified":"2025-07-22T15:55:33","modified_gmt":"2025-07-22T12:55:33","slug":"sea-urchin-embryos-reveal-insights-into-human-skeletal-development","status":"publish","type":"post","link":"https:\/\/marsci.haifa.ac.il\/en\/sea-urchin-embryos-reveal-insights-into-human-skeletal-development\/","title":{"rendered":"Sea Urchin Embryos Reveal Insights into Human Skeletal Development"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"34251\" class=\"elementor elementor-34251\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-8cd7cd4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8cd7cd4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-faec414\" data-id=\"faec414\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-29e60d0 elementor-widget elementor-widget-text-editor\" data-id=\"29e60d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"flex max-w-full flex-col flex-grow\"><div class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"75026dd8-f4fd-412b-a03f-4b1cf3cc3550\" data-message-model-slug=\"gpt-4o\"><div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\"><div class=\"markdown prose w-full break-words dark:prose-invert light\"><div class=\"flex max-w-full flex-col flex-grow\"><div class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words text-start [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"2f76db14-7eca-4d73-90fd-1ef25775a6e1\" data-message-model-slug=\"gpt-4o\"><div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\"><div class=\"markdown prose w-full break-words dark:prose-invert light\"><h1 style=\"text-align: center;\"><strong>A common mechanical sensing mechanism controls sea urchins and humans skeletal formation<\/strong><\/h1><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-bb24674 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bb24674\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dc947e0\" data-id=\"dc947e0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-004b1aa elementor-widget elementor-widget-text-editor\" data-id=\"004b1aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"flex max-w-full flex-col flex-grow\"><div class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words text-start [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"1b501a91-a0a9-4cbf-b36b-3e0acaf618e8\" data-message-model-slug=\"gpt-4o\"><div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\"><div class=\"markdown prose w-full break-words dark:prose-invert light\"><p>Prof. Smadar Ben-Tabou de-Leon and her team from the Laboratory for Regulation and Evolution of Development (RED Lab) at the Department of Marine Biology have made a groundbreaking discovery, now published in the prestigious journal <em>PNAS<\/em>!<\/p><p>The study uncovered an unexpected similarity between skeletal formation in sea urchins and bone development in humans. The researchers identified a shared mechanical sensing circuit in both organisms that detects skeletal rigidity and regulates its growth.<\/p><p>This significant discovery enhances our understanding of fundamental biological processes and may pave the way for developing innovative treatments for pathological calcification.<\/p><p><strong>Research Team<\/strong>: Dr. Majed Layous, Dr. Tsvia Gildor, Tovah Nehrer, and Areen Qassem from Prof. Ben-Tabou de-Leon&#8217;s lab, along with Prof. Haguy Wolfenson from the Technion \u2013 Israel Institute of Technology.<\/p><ul><li><a href=\"https:\/\/bit.ly\/4a2mkBM\" target=\"_new\" rel=\"noopener nofollow\">Read the full paper in PNAS<\/a><\/li><li><a href=\"https:\/\/bit.ly\/40jZGBv\" target=\"_new\" rel=\"noopener nofollow\">Explore the Haaretz article<\/a><\/li><li><a href=\"https:\/\/lnkd.in\/dTJtyVkx\" target=\"_new\" rel=\"noopener nofollow\">Listen to Prof. Ben-Tabou de-Leon\u2019s interview on the &#8220;Three Who Know&#8221; program (starts at 29:30)<\/a><\/li><\/ul><p>\ud83d\udcf8 <em>The image displays focal adhesion complexes around the sea urchin larval skeleton, which allow cells to sense biominerals.<\/em><br \/><em>Image credit: Dr. Tsvia Gildor.<\/em><\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-section elementor-top-section elementor-element elementor-element-487c5b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"487c5b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1867828\" data-id=\"1867828\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca16c75 elementor-widget elementor-widget-image\" data-id=\"ca16c75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"768\" src=\"https:\/\/marsci.haifa.ac.il\/wp-content\/uploads\/2025\/01\/Cover-2-768x768.png\" class=\"attachment-medium_large size-medium_large wp-image-34216\" alt=\"\" srcset=\"https:\/\/marsci.haifa.ac.il\/wp-content\/uploads\/2025\/01\/Cover-2-768x768.png 768w, https:\/\/marsci.haifa.ac.il\/wp-content\/uploads\/2025\/01\/Cover-2-300x300.png 300w, https:\/\/marsci.haifa.ac.il\/wp-content\/uploads\/2025\/01\/Cover-2-1024x1024.png 1024w, https:\/\/marsci.haifa.ac.il\/wp-content\/uploads\/2025\/01\/Cover-2-150x150.png 150w, 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PNAS!<\/p>\n","protected":false},"author":3,"featured_media":34212,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":"","_wp_rev_ctl_limit":""},"categories":[105],"tags":[],"class_list":["post-34251","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-archive","entry","has-media"],"acf":[],"_links":{"self":[{"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/posts\/34251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/comments?post=34251"}],"version-history":[{"count":0,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/posts\/34251\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/media\/34212"}],"wp:attachment":[{"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/media?parent=34251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/categories?post=34251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/marsci.haifa.ac.il\/en\/wp-json\/wp\/v2\/tags?post=34251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}