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Cnidarians Developmental Biology and Molecular Ecology

Head of the Lab: Dr. Tamar Lotan


Publications

Publications and Patents

Refereed Journals:

  •  cover4Atkinson, S.D., Bartholomew, J.L., Lotan, T. Myxozoans: Ancient metazoan parasites find a home in phylum Cnidaria. Zoology 129, 66-68, 2018 https://doi.org/10.1016/j.zool.2018.06.005
  • Lövy A., Smirnov M., Brekhman V., Ofek T., Lotan T. Morphological and molecular characterization of a novel myxosporean parasite Myxobolus bejeranoi n. sp.(Cnidaria: Myxosporea) from hybrid tilapia in Israel. Parasitology Resarch: 1-9, 2017 doi:10.1007/s00436-017-5725-2
  • Piriatinskiy G., Atkinson SD, Park S, Morgenstern D, Brekhman V, Yossifon G, Bartholomew JL, Lotan T. Functional and proteomic analysis of Ceratonova shasta (Cnidaria: Myxozoa) polar capsules reveals adaptations to parasitism. Scientific Reports 7:9010, 2017; doi: 10.1038/s41598-017-09955-y.
  • Agron, M., Brekhman, V., Morgenstern, D., Lotan, T.  Regulation of AP-1 by MAPK signaling in metal-stressed sea anemone. Cell Physiol Biochem 42(3):952-964, 2017 https://doi.org/10.1159/000478678

MAPK signaling

  • ELECTROPHORESIS 2017 coverPark, S., Capelin, D., Piriatinskiy, G., Lotan, T., Yossifon, G.  Dielectrophoretic characterization and isolation of jellyfish stinging capsules. Electrophoresis, 38:1996–2003, 2017; https://doi.org/10.1002/elps.201700072
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  • Park, S., Piriatinskiy, G., Zeevi, D., Ben-David, J., Yossifon, G., Shavit, U. and Lotan, T. The nematocyst’s sting is driven by the tubule moving front. Journal of the Royal Society Interface, 14: 20160917, 2017 DOI: 10.1098/rsif.2016.0917 (For the movie please see this link). 
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  • Ben-David, J., Atkinson,SD.,  Pollak,Y.,  Yossifon, G., Shavit, U., Bartholomew, JL. and Lotan, T.  Myxozoan polar tubules display structural and functional variation. Parasit Vectors, 9:549, 2016. doi:  10.1186/k016-1819-4 (open access).

  • Levitan S., Sher N., Brekhman V., Ziv T., Lubzens E. and Lotan T. The making of an embryo in a basal metazoan: proteomic analysis in the sea anemone Nematostella vectensis. Proteomics  2015.
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  • Brekhman, V., Malik, A., Haas, B., Sher, N. and Lotan, T. Transcriptome profiling of the dynamic life cycle of the scypohozoan jellyfish Aurelia aurita. BMC Genomics 16:74, 2015.
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  • Rachamim, T., Morgenstern, D., Aharonovich, D., Brekhman, V., Lotan, T and Sher, D. The dynamically-evolving nematocyst content of an Anthozoan, a Scyphozoan and a Hydrozoan.  Molecular Biology and Evolution 32 (3) 740-753, 2015.
    Read More...MOLECULAR ECOLOGY

  • Elran R., Raam M., Kraus R., Brekhman V., Sher N., Plaschkes, I., Califa-Capsi V., Lotan T. Early and late response of Nematostella vectensis transcriptome to heavy metals. Molecular Ecology, 23:19 4722-4736, 2014 
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  • Hensel, K, Lotan, T, Sanders, S.M, Cartwright, P. and Frank U. Lineage-specific evolution of cnidarian Wnt ligand. Evolution & Development, 16:5, 259–269, 2014.
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  • Tal. Y, Sharaev, A, Kazir Z, Brekhman, V Lotan, T Continuous Drug Release by Sea Anemone Nematostella vectensis Stinging Microcapsules. Marine Drugs 12(2): 734-745, 2014.
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  • Lotan T, Chalifa-Caspi V, Ziv T, Brekhman V, Gordon MM, Admon A, Lubzens E. Evolutionary conservation of the mature oocyte proteome. EuPA Open Proteomics 3: 27-36, 2014.
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  • Shaoul, E., Ayalon, A., Tal. Y., & Lotan, T. Systemic drug delivery of scopolamine ‎using cnidocysts PloS ONE 7(2) e31922, 2012.
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  • Yoffe, C., Lotan, T., Benayhu, Y. A modified view on Octocorals: Heteroxenia ‎fuscescenes nematocysts are diverse featuring ancestral and novel type. PLoS ONE 7(2):e31902, 2012.
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  • Ayalon A., Schichor I., Tal Y. and Lotan, T. Immediate topical drug delivery by natural submicron injectors. Int J Pharm 419:147-153, 2011.
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  • Lotan, T. Ohto, M-A., Matsudaria Yee, K., West, M.A.L., Lo, R. Kwong, R.W. Yamagishi, K., Fischer, R.L., Goldberg, R.B. and Harada, J.J. Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryp development in vegetative cells. Cell 93:1195-1205, 1998.  
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  • Harada, J.J., Lotan, T., Fischer, R.L. and Goldberg, R.B. Embryos without sex. Trends Plant Sci. 3:452-453, 1998.
  • Hirschberg, J.,Cohen, M., Harker, M., Lotan,T., Mann, V. and Pecker, I. Molecular genetics of the carotenoid biosynthesis pathway in plants and algae. Pure & Appl. Chem., 69:2151-2158, 1997.
  • Lotan, T. and Hirschberg, J. Cloning an expression in Escherichia coli of the gene encoding b-C-4-oxygenase, that converts ?-carotene to the ketocarotenoid cantahxanthin in Haematococcus pluvialis. FEBS 364:125-128, 1995.
  • Eyal-Giladi, H., Lotan, T., Levin,T., Avner, O. and Hochman, J. Avian marginal zone cells function as primitive streak inducers only after their migration into the hypoblast. Development 120:2501-2509, 1994.
  • Ori, N., Sessa, G., Lotan, T., Himmelhoch, S. and Fluhr, R. A major stylar matrix polypeptide (sp41) is a member of the pathogenesis-related proteins superclass. EMBO J. 9: 3429-3436, 1991.
  • Fluhr, R., G. Sessa, A. Sharon, N. Ori and T. Lotan. Pathogenesis-related proteins exhibit both pathogen-induced and developmental regulation. In: Proceedings of the 5th International Symp. on: Molecular Genetics of Plant-Microbe Interaction. Hennecke, H., ed. Kluwer Acad. Publishers, Dordrecht, The Netherlands. 1:387-394, 1990.
  • Lotan, T. and Fluhr, R. Function and regulation accumulation of plant pathogenesis-related proteins. Symbiosis 8:33-46, 1990.
  • Lotan, T. and Fluhr, R. Xylanase, a Novel elicitor of pathogenesis-related proteins in tobacco, uses a non-ethylene pathways for induction. Plant Physiol. 93:811-817, 1990.
  • Lotan, T., Ori, N. and Fluhr, R. Pathogenesis-related proteins are developmentally regulated in tobacco flowers. Plant Cell 1:881-887, 1989.

Book Chapters:

  • Lotan, T., The effect of the jellyfish proliferation – ramifications on the national level. In: Maritime Strategic Evaluation for Israel 2018/19 Horev, S. & Gonen, A. (eds.) 269-279, 2019.
  • Lotan, T., Tal. Y., Ayalon, A. Fast acting topical hydrophilic drug delivery via a natural nano-injection system. In: Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement, Dragicevic-Curic, N. & Maibach, H. I. (eds.) (Springer Berlin Heidelberg). Chap: 21 343-350, 2017.
  • Lotan T. Leveraging nematocysts toward human care. The Cnidaria, past, present and future, The world of Medusa and her sisters. 1st edition. Goffredo, G. and Dubinsky, Z. (eds). (Springer International Publishing). Chap: 42 683-690, 2016
  • Lotan, T, Jellyfish a winning structure. In: The Glory of the Sea: Stability and Change in the Aquatic Systems of Israel, 1st edition, Stambler,N., Lotan, T., Goodman, B., Berman-Frank, I. (Eds.), Chap 14:158-166, 2013.
  • Lotan, T. Immediate topical drug delivery using natural nano-injectors. In: Modified Release Drug Delivery Technology, 2nd edition, Hadgraft J., Rathbone M. and Lane M. (Eds.),  2008.
  • Lotan, T. Natural nano-injectors as a vehicle for novel topical drug delivery. In: Precutaneous absorption, 4th edition, Bronaugh, R. L. & Maibach, H. I. (Eds.), 2005.

Edited Books:

  • The Glory of the Sea: Stability and Change in the Aquatic Systems of Israel, 1st edition, Stambler,N., Lotan, T., Goodman, B., Berman-Frank, I. (eds) , 2013.
    Guest Editor:
  • Benayahu, Y., Levy, O. and Lotan, T. Coelenterate Biology: Advanced studies on Cnidaria and Ctenophora- special volume in the Hydrobiologia journal- 759:1-2. 2015

Patents Granted:

  • Lotan, T. and Eckhouse, S. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent. EP patent EP 1956894, 2016
  • Lotan, T. and Eckhouse, S. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent. US patent 8,834,862, 2014
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. Israel patent 199236, 2014
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. US Patent 8,486,441, 2013.
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. US patent 8,297,912, 2012.
  • Lotan, T., Eckhouse, S., Shaoul, E. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive there from for delivering the therapeutic, diagnostic or cosmetic agent into a tissue. US patent 8,337,868, 2012.
  • Lotan, T., and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. EP patent 1379127.
  • Lotan, T. and Eckhouse, S. Use of stinging cells/capsules for the delivery of active agents to keratinous substances. US patent 7,998,509, 2011.
  • Lotan, T., Eckhouse S., Shaoul, E. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive there from for delivering the therapeutic, diagnostic or cosmetic agent into a tissue. Israel patent 2003164191, 2011.
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. US patent 8,062,660, 2011.
  • Lotan, T. and Eckhouse, S. Compositions of matter and pharmaceutical compositions comprising stinging capsules and cosmetic agents. Israel patent 2001155097, 2011.
  • Lotan, T. and Eckhouse, S. Use of stinging cells/capsules for the delivery of active agents to keratinous substances. US patent 7,998,509, 2011.
  • Lotan, T. and Eckhouse, S. Use of stinging cells/capsules for the delivery of active agents to keratinous substances. US patent 7,632,522, 2009.
  • Lotan, T., Eckhouse, S., Shaoul, E. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive there from for delivering the therapeutic, diagnostic or cosmetic agent into a tissue. US patent 7,611,723, 2009.
  • Lotan, T., Eckhouse S., Shaoul, E. Stinging cells expressing an exogenous polynucleotide encoding a therapeutic, diagnostics or a cosmetic agent and methods compositions and devices utilizing such stinging cells or capsules derive there from for delivering the therapeutic, diagnostic or cosmetic agent into a tissue. EP patent 1519755 2008.
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. US patent 7,338,665, 2008.
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering therapeutic or a cosmetic agent into a tissue. US patent 6,923,976, 2005.
  • Hirschberg, J. and Lotan, T. Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants. US patent 6,903,245, 2005.
  • Harada, JJ, Lotan, T., Ohto, M-a., Goldberg, RB, Fischer, RL. Leafy cotyledon1 genes and their uses. US patent 6,781,035, 2004.
  • Harada, JJ., Lotan, T., Ohto, M-a., Goldberg, RB, Fischer, RL. Leafy cotyledon1 genes and their uses. US patent 6,545,201, 2003.
  • Lotan, T. and Eckhouse, S. Methods utilizing stinging cells/capsules. US patent 6,613,344, 2003.
  • Harada, JJ., Lotan T., Ohto, M-a., Goldberg, RB., Fischer, RL. Leafy cotyledon genes and their uses. US patent 6,320,102, 2001.
  • Harada, JJ., Lotan T., Ohto, M-a., Goldberg, RB., Fischer, RL. Leafy cotyledon1 genes and methods of modulating embryo development in transgenic plants. US patent 6,235,975, 2001.
  • Hirschberg, J. and Lotan, T. Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants. US patent 6,218,599, 2001.
  • Hirschberg, J. and Lotan, T. Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants. US patent 5,965,795, 1999.
  • Hirschberg, J. and Lotan, T. Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S,3S) astaxanthin. US patent 5,916,791, 1999.

Patents Pending:

  • Eckhouse, S., Lotan T., Ayalon, A. Pharmaceutical compositions and delivery devices comprising stinging cells or capsules. US patent application 20150250714, 2015
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. Israel patent application 2001199236.
  • Lotan, T. and Eckhouse, S. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent. US patent application 11/108,662.
  • Lotan, T. and Eckhouse, S. Methods compositions and devices utilizing stinging cells/capsules for delivering a therapeutic or a cosmetic agent into a tissue. EP patent application 2006 06728266.5
  • Eckhouse, S., Lotan T., Ayalon, A. Pharmaceutical compositions and delivery devices comprising stinging cells or capsules. US patent application 13/882,192, 2013.

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